Abstract Background We have previously reported that p53 mutated radioresistant lymphoma cell lines undergo mitotic catastrophe after irradiation. resulting in metaphase arrest and the generation of endopolyploid cells. A proportion of these endopolyploid cells then undergo a process of de-polyploidisation. stages of which are partially reminiscent of meiotic prophase. https://www.izztop.com/product-category/brink/